基本信息
职称：助理研究员
地址：mobile365（逸夫楼）
个人简介
陈凯，男，1986年10月生，博士，助理研究员。
学习经历
2009-2014 北京大学化学与分子工程学院，理学博士学位
2005-2009 南开大学药学院，药学学士
任职情况：
2017.6至今 mobile365，助理研究员
2015.5-2017.5 华南理工大学化学与化工学院，助理研究员
主要研究方向
基于计算化学辅助的林源活性化学物开发
科研项目
1. 主持广东省自然基金项目1项，项目名称：过渡金属催化的基于邻苯碳醌中间体的反应机理研究，资助金额：10万元，项目时间：2016-2019。
2. 主持中央高校基本科研业务费自然科学类-博士启动项目1项，项目名称：“基于金属卡宾的结构性质预测其反应活性和选择性的理论和实验研究”，资助金额：5万元，项目时间：2017-2018。
发表文章
在国际重要期刊共发表文章22篇，其中以第一作者或者通讯作者发表文章9篇，累计被引用次数超过200。
第一作者或通讯作者：
1. Kai Chen, Xiaoxiao Zhang, Yun-Dong Wu, Olaf Wiest*, “Inhibition and Mechanism of HDAC8 Revisited”, J. Am. Chem. Soc. 2014, 136, 11636. (IF: 13.0)
2. Kai Chen#, Feng Wu#, Lijuan Ye, Zi-You Tian, Zhi-Xiang Yu*, Shifa Zhu*, “Cycloaddition Reaction of Vinylphenylfurans and Dimethyl Acetylenedicarboxylate to [8+2] Isomers via Tandem [4+2]/Diradical Alkene-Alkene Coupling/[1,3]-H Shift Reactions: Experimental Exploration and DFT Understanding of Reaction Mechanisms”, J. Org. Chem. 2016, 81, 8155. (IF: 4.8)
3. Kai Chen, Shifa Zhu*, “NHC-AuCl/Selectfluor: An Efficient Catalytic System for π-Bond Activation”, Synlett. 2017, 28, 640. (IF: 2.3)
4. Jiantao Zhang, Yelin Xiao, Kai Chen*, Wanqing Wu, Huanfeng Jiang, and Shifa Zhu*, “Zinc-Catalyzed Tandem Diels-Alder Reactions of Enynals with Alkenes: Generations of Cyclic o-Quinodimethanes (o-QDMs)”, Adv. Synth. Catal. 2016, 358, 2684. (IF: 6.5)
5. Min Zheng, Feng Wu, Kai Chen*,and Shifa Zhu*, “Styrene as 4π-Component in Zn(II)-Catalyzed Intermolecular Diels-Alder/Ene-Tandem Reactions”, Org. Lett. 2016, 18, 3554. (IF: 6.7)
6. Hong-Xin Liu, Liyun Zhao, Yunfei Yuan, Zhifang Xu, Kai Chen*, Shengxiang Qiu*, Haibo Tan*, “Potassium Thioacids Mediated Selective Amide and Peptide Constructions Enabled by Visible Light Photoredox Catalysis”, ACS Catalysis 2016, 6, 1732. (IF: 9.3)
7. Haibo Tan, Hong-Xin Liu, Xinzheng Chen, Yunfei Yuan, Kai Chen*, Shengxiang Qiu*, “Concise Construction of the Tricyclic Core of Bullataketals Enabled by a Biomimetic Intermolecular (3 + 3) Type Cycloaddition”, Org. Lett. 2015, 17, 4050. （IF: 6.7）
8. Kai Chen, Liping Xu, Olaf Wiest*, “Computational Exploration of Zinc Binding Groups for HDAC Inhibition”, J. Org. Chem. 2013, 78, 5051. (IF: 4.8)
9. Kai Chen, Zhe-Chen Wang, Maria Schlangen, Yun-Dong Wu, Xinhao Zhang*, Helmut Schwarz*, “Thermal Activation of Methane and Ethene by Bare MO?+ (M=Ge, Sn, and Pb): A Combined Theoretical/Experimental Study”, Chem. Eur. J. 2011, 17, 9619.(Cover) (IF: 5.8)
合作发表文章：
10. Min Zheng, Kai Chen, Shifa Zhu*, “One-pot Synthesis of Indole Derivatives from the Reaction of Nitroalkynes and Alkynes through Hg-Carbene Intermediate, Synthesis”, 2017, 49, 4173.
11. Tongxiang Cao, Kai Chen, Shifa Zhu*, “An efficient Approach to Generate Aryl Carbene: Gold-Catalyzed Sequential Activation of 1,6-Diynes” Org. Chem. Front. 2017, 4, 450.
12. Hejiang Luo, Kai Chen, Huanfeng Jiang, Shifa Zhu*, “A Route to Polysubstituted Aziridines from Carbenes and Imines through a Nondiazo Approach”, Org. Lett. 2016, 5208.
13. Hong-Xin Liu, Kai Chen, Gui-Hua Tang, Yun-Fei Yuan, Haibo Tan*, ShengXiang Qiu*, “Isolation and Biomimetic Total Synthesis of Tomentodiones A-B, Terpenoid- conjugated Phloroglucinols from the Leaves of Rhodomyrtus tomentosa”, RSC Advances 2016, 6, 48231.
14. Jun Ma, Kai Chen, Hongguang Fu, Li Zhang, Wanqing Wu, Huanfeng Jiang, Shifa Zhu*, “Dual Catalysis: Proton/Metal-Catalyzed Tandem Benzofuran Annulation/Carbene Transfer Reaction”, Org. Lett. 2016, 18, 1322.
15. Renxiao Liang, Kai Chen, Qiaohui Zhang, Jiantao Zhang, Huanfeng Jiang, Shifa Zhu*, “Rapid Access to 2-Methylene Tetrahydrofurans and γ-Lactones: A Tandem Four-Step Process”, Angew. Chem. Int. Ed. 2016, 55, 2587.
16. Hong-Xin Liu, Kai Chen, Yao Yuan, Zhi-Fang Xu, Hai-Bo Tan*, Sheng-Xiang Qiu*, “Rhodomentones A and B, novel meroterpenoids with unique NMR characteristics from Rhodomyrtus tomentosa” Org. Biomol. Chem. 2016, 14, 7354.
17. Hong-Xin Liu, Kai Chen, Qian-Yun Sun, Fu-Mei Yang, Guang-Wan Hu, Yue-Hu Wang*, Chun-Lin Long*, “Nudibaccatumone, a Trimer Comprising a Phenylpropanoid and Two Sesquiterpene Moieties from Piper Nudibaccatum”, J. Nat. Prod. 2013, 4, 732.
18. Xiaoxiao Zhagn, Kai Chen, Yun-Dong Wu, Olaf Wiest, “Protein Dynamics and Structural Waters in Bromodomains”, PloS ONE, 2017, 12, e0186570 (ASAP).
19. Yuefeng Zhou, Jun Ma, Kai Chen, Huanfeng Jiang, Shifa Zhu*, “Selectivitiy-Switchable Oxidation of Tetraarylenthylenes to Fused Polycyclic Comounds”, Chem. Commun. 2016, 52, 13345.
20. Shifa Zhu*, Qiaohui Zhang, Kai Chen, Huanfeng Jiang, “Synergistic Catalysis: Metal/Proton-Catalyzed Cyclization of Alkynones Toward Bicyclo[3.n.1]alkanones”, Angew. Chem. Int. Ed. 2015, 54, 9414.
21. Lina Guo, Taibao Liu, Kai Chen, Tianbang Song, Peng George Wang*, Wei Zhao*, “Facile Synthesis of 5-hydroxy-L-lysine from D-galactose as a Chiral-precursor”, Org. Biomol. Chem. 2014, 12, 7310.
22. Nicolas Dietl, Torsten Wende, Kai Chen, Ling Jiang, Maria Schlangen, Xinhao Zhang, Knut R. Asmis*, Helmut Schwarz*, “Structure and Chemistry of the Heteronuclear Oxo-Cluster [VPO4]?+: A Model System for the Gas-Phase Oxidation of Small Hydrocarbons”, J. Am. Chem. Soc. 2013, 135, 3711.